Structure of PDB 7kr9 Chain A

Receptor sequence
>7kr9A (length=453) Species: 373153 (Streptococcus pneumoniae D39) [Search protein sequence]
SNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQPEKTVTV
VGHKAELVEETEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAGDTPLI
TGESLKNLIDFHINHKNVATILTAETDNPFGYGRIVRNDNAEVLRIVEQK
DATDFEKQIKEINTGTYVFDNERLFEALKNINTNNAQGEYYITDVIGIFR
ETGEKVGAYTLKDFDESLGVNDRVALATAESVMRRRINHKHMVNGVSFVN
PEATYIDIDVEIAPEVQIEANVILKGQTKIGAETVLTNGTYVVDSTIGAG
AVITNSMIEESSVADGVTVGPYAHIRPNSSLGAQVHIGNFVEVKGSSIGE
NTKAGHLTYIGNCEVGSNVNFGAGTITVNYDGKNKYKTVIGDNVFVGSNS
TIIAPVELGDNSLVGAGSTITKDVPADAIAIGRGRQINKDEYATRLPHHP
KNQ
3D structure
PDB7kr9 Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.157: glucosamine-1-phosphate N-acetyltransferase.
2.7.7.23: UDP-N-acetylglucosamine diphosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO A Y365 V384 N385 Y386 Y359 V378 N379 Y380
BS02 ZN A E315 H330 E309 H324
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0019134 glucosamine-1-phosphate N-acetyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0000902 cell morphogenesis
GO:0006048 UDP-N-acetylglucosamine biosynthetic process
GO:0008360 regulation of cell shape
GO:0009058 biosynthetic process
GO:0009245 lipid A biosynthetic process
GO:0009252 peptidoglycan biosynthetic process
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:7kr9, PDBe:7kr9, PDBj:7kr9
PDBsum7kr9
PubMed35021083
UniProtQ04KU2|GLMU_STRP2 Bifunctional protein GlmU (Gene Name=glmU)

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