Structure of PDB 7kr4 Chain A

Receptor sequence

>7kr4A (length=639) Species: 9606 (Homo sapiens) [Search protein sequence]

SNDMDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLR
MVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKA
VAQATGRQLESVRAEAAEKGDVGLVAENSRSTPPPPLTASGVFSKFRDIA
RLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAA
LSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPD
LDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAA
FTCEYKYDGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIKLPS
VTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDL
IYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLE
QSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVI
GAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSL
KALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLV
DSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQS

3D structure

PDB

7kr4 High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication.

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

6.5.1.1: DNA ligase (ATP).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	A346 G348 V349 G350 G352 V353 G571 Q572 S588 R589 F635 F872	A89 G91 V92 G93 G95 V96 G309 Q310 S326 R327 F373 F610
BS02	dna	A	S303 R305 R549 Y749 T798 G799 F800 S801 D802 F872 R874	S46 R48 R287 Y487 T536 G537 F538 S539 D540 F610 R612
BS03	dna	A	R305 T415 G416 S417 A418 T420 R451 G453 A455 Q457 S458 H546 Q636 T639 T640 R641 K642 R643 R768 G769 K770 R771 G776 C794 K795 G797 S850 L851 S852 P853 Y855 S869 L870 F872	R48 T153 G154 S155 A156 T158 R189 G191 A193 Q195 S196 H284 Q374 T377 T378 R379 K380 R381 R506 G507 K508 R509 G514 C532 K533 G535 S588 L589 S590 P591 Y593 S607 L608 F610
BS04	AMP	A	K568 Y569 R573 E621 F660 M723 K725 K744	K306 Y307 R311 E359 F398 M461 K463 K482

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005524	ATP binding

	Biological Process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0071897	DNA biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7kr4, PDBe:7kr4, PDBj:7kr4
PDBsum	7kr4
PubMed	33473124
UniProt	P18858\|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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