Structure of PDB 7kpm Chain A

Receptor sequence
>7kpmA (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
AKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEK
QRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLR
QNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKV
SDFPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDV
INAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIR
NPASL
3D structure
PDB7kpm Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.
ChainA
Resolution1.608 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D744 A746 R748 N749 D762 P787
Catalytic site (residue number reindexed from 1) D134 A136 R138 N139 D152 P154
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A I625 G626 A627 G628 E629 F630 V633 A649 K651 M700 L751 I15 G16 A17 G18 E19 F20 V23 A39 K41 M90 L141
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7kpm, PDBe:7kpm, PDBj:7kpm
PDBsum7kpm
PubMed33627480
UniProtP54762|EPHB1_HUMAN Ephrin type-B receptor 1 (Gene Name=EPHB1)

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