Structure of PDB 7kng Chain A

Receptor sequence

>7kngA (length=519) Species: 6239 (Caenorhabditis elegans)

AMANNSSVANKVCLIVIDGWGVSEDPYGNAILNAQTPVMDKLCSGNWAQI
EAHGLHVGLPEGLMGNSEVGHLNIGAGRVIYQDIVRINLAVKNNKFVTNE
SLVDACDRAKNGNGRLHLAGLVSDGGVHSHIDHMFALVKAIKELGVPELY
LHFYGDGRDTSPNSGVGFLEQTLEFLEKTTGYGKLATVVGRYYAMDRDNR
WERINVAYEAMIGGVGETSDEAGVVEVVRKRYAADETDEFLKPIILQGEK
GRVQNDDTIIFFDYRADRMREISAAMGMDRYKDCNSKLAHPSNLQVYGMT
QYKAEFPFKSLFPPASNKNVLAEWLAEQKVSQFHCAETEKYAHVTFFFNG
GLEKQFEGEERCLVPSPKVATYDLQPEMSAAGVADKMIEQLEAGTHPFIM
CNFAPPDMVGHTGVYEAAVKACEATDIAIGRIYEATQKHGYSLMVTADHG
NAEKMKAPDGGKHTAHTCYRVPLTLSHPGFKFVDPADRHPALCDVAPTVL
AIMGLPQPAEMTGVSIVQK

3D structure

• PDB: 7kng Structure-activity relationship of ipglycermide binding to phosphoglycerate mutases.
• Chain: A
• Resolution: 2.1 Å

Enzymatic activity

• Enzyme Commision number: 5.4.2.12: phosphoglycerate mutase (2,3-diphosphoglycerate-independent).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	L82 N85 E87 V88 Q101 D102 R284 R289 T319 P333 N336 F366 H430 H485	L63 N66 E68 V69 Q82 D83 R265 R270 T300 P314 N317 F347 H411 H466
BS02	ZN	A	D37 S86 D467 H468	D18 S67 D448 H449
BS03	ZN	A	D426 H430 H485	D407 H411 H466

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004619 phosphoglycerate mutase activity
• GO:0016853 isomerase activity
• GO:0030145 manganese ion binding
• GO:0046537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0006007 glucose catabolic process
• GO:0006096 glycolytic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7kng, PDBe:7kng, PDBj:7kng
• PDBsum: 7kng
• PubMed: 33812994
• UniProt: G5EFZ1|GPMI_CAEEL 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (Gene Name=ipgm-1)