Structure of PDB 7knf Chain A

Receptor sequence

>7knfA (length=506) Species: 6239 (Caenorhabditis elegans)

VANKVCLIVIDGWGVSEDPYGNAILNAQTPVMDKLCSGNWAQIEAHGLHV
GLPEGLMGNSEVGHLNIGAGRVIYQDIVRINLAVKNNKFVTNESLVDACD
RAKNGNGRLHLAGLVSDGGVHSHIDHMFALVKAIKELGVPELYLHFYGDG
RDTSPNSGVGFLEQTLEFLEKTTGYGKLATVVGRYYAMDRDNRWERINVA
YEAMIGGVGETSDEAGVVEVVRKRYAADETDEFLKPIILQGEKGRVQNDD
TIIFFDYRADRMREISAAMGMSKLAHPSNLQVYGMTQYKAEFPFKSLFPP
ASNKNVLAEWLAEQKVSQFHCAETEKYAHVTFFFNGGLEKQFEGEERCLV
PSPKVATYDLQPEMSAAGVADKMIEQLEAGTHPFIMCNFAPPDMVGHTGV
YEAAVKACEATDIAIGRIYEATQKHGYSLMVTADHGNAEKMKAPDGGKHT
AHTCYRVPLTLSHPGFKFVDPADRHPALCDVAPTVLAIMGLPQPAEMTGV
SIVQKI

3D structure

• PDB: 7knf Structure-activity relationship of ipglycermide binding to phosphoglycerate mutases.
• Chain: A
• Resolution: 1.8 Å

Enzymatic activity

• Enzyme Commision number: 5.4.2.12: phosphoglycerate mutase (2,3-diphosphoglycerate-independent).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	N85 E87 V88 Q101 D102 R284 R289 T319 P333 F366 H485	N59 E61 V62 Q75 D76 R258 R263 T286 P300 F333 H452
BS02	peptide	A	S86 H485	S60 H452
BS03	ZN	A	D37 S86 D467 H468	D11 S60 D434 H435
BS04	ZN	A	D426 H430 H485	D393 H397 H452

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004619 phosphoglycerate mutase activity
• GO:0016853 isomerase activity
• GO:0030145 manganese ion binding
• GO:0046537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0006007 glucose catabolic process
• GO:0006096 glycolytic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7knf, PDBe:7knf, PDBj:7knf
• PDBsum: 7knf
• PubMed: 33812994
• UniProt: G5EFZ1|GPMI_CAEEL 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (Gene Name=ipgm-1)