Structure of PDB 7kma Chain A

Receptor sequence
>7kmaA (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
DDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTS
AIETLCGVDSSVAVSSGGELFLRFISDYSKCKKIMIERGELFLRRISLSR
NKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPD
LSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIIN
KIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKDLKEE
HPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYLG
3D structure
PDB7kma Sugar phosphate activation of the stress sensor eIF2B.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M6P A Y130 S131 R132 G196 A197 E198 N208 K209 K234 Y122 S123 R124 G188 A189 E190 N200 K201 K226
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0009408 response to heat
GO:0009749 response to glucose
GO:0014003 oligodendrocyte development
GO:0043434 response to peptide hormone
GO:0044237 cellular metabolic process
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kma, PDBe:7kma, PDBj:7kma
PDBsum7kma
PubMed34103529
UniProtQ14232|EI2BA_HUMAN Translation initiation factor eIF2B subunit alpha (Gene Name=EIF2B1)

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