Structure of PDB 7kl1 Chain A

Receptor sequence

>7kl1A (length=268) Species: 9606 (Homo sapiens)

TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQK
LEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY
YSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLAD
FGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL
LVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP
SKRITAAEALKHPWISHR

3D structure

• PDB: 7kl1 CaMKII binds both substrates and activators at the active site.
• Chain: A
• Resolution: 2.4 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): N135 K137 N140 D156 T176
• Catalytic site (residue number reindexed from 1): N129 K131 N134 D150 T170
• Enzyme Commision number: 2.7.11.17: calcium/calmodulin-dependent protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	E96 F98 E99 N135 E139 F173 A174 G175 T176 P177 Y210 P211 P212 W214 Q218	E90 F92 E93 N129 E133 F167 A168 G169 T170 P171 Y204 P205 P206 W208 Q212
BS02	peptide	A	G22 A23 F24 N45 K47 L49	G16 A17 F18 N39 K41 L43
BS03	MG	A	N140 D156	N134 D150
BS04	ATP	A	L19 A40 L91 V92 E96 K137 N140 L142 D156	L13 A34 L85 V86 E90 K131 N134 L136 D150

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:7kl1, PDBe:7kl1, PDBj:7kl1
• PDBsum: 7kl1
• PubMed: 35830796
• UniProt: Q9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)