Structure of PDB 7kl0 Chain A

Receptor sequence

>7kl0A (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]

TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQK
LEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY
YSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLAD
FGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL
LVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP
SKRITAAEALKHPWISHR

3D structure

PDB

7kl0 CaMKII binds both substrates and activators at the active site.

Chain

Resolution

2.4 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	N135 K137 N140 D156 T176
Catalytic site (residue number reindexed from 1)	N129 K131 N134 D150 T170
Enzyme Commision number	2.7.11.17: calcium/calmodulin-dependent protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	K56 E96 F98 E99 N135 K137 E139 F173 A174 G175 T176 P177 I205 Y210 P211 W214 E236	K50 E90 F92 E93 N129 K131 E133 F167 A168 G169 T170 P171 I199 Y204 P205 W208 E230
BS02	peptide	A	G22 A23 F24 N45 K47	G16 A17 F18 N39 K41
BS03	UZD	A	A40 F89 D90 L91 V92 L142 D156	A34 F83 D84 L85 V86 L136 D150

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7kl0, PDBe:7kl0, PDBj:7kl0
PDBsum	7kl0
PubMed	35830796
UniProt	Q9UQM7\|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)

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