Structure of PDB 7kko Chain A

Receptor sequence
>7kkoA (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVV
NKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYI
GGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRV
TLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEY
LITYQIMKPE
3D structure
PDB7kko Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
ChainA
Resolution1.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1234 H1237 C1242 C1245 C130 H133 C138 C141
BS02 09L A H1184 G1185 I1192 F1197 D1198 H1201 Y1203 I1212 Y1213 F1214 A1215 S1221 Y1224 I1228 H80 G81 I88 F93 D94 H97 Y99 I108 Y109 F110 A111 S117 Y120 I124 BindingDB: IC50=1230nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7kko, PDBe:7kko, PDBj:7kko
PDBsum7kko
PubMed33361107
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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