Structure of PDB 7kkn Chain A

Receptor sequence
>7kknA (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVV
NKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAGG
MFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTL
GKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLI
TYQIMKP
3D structure
PDB7kkn Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
ChainA
Resolution1.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1234 H1237 C1242 C1245 C128 H131 C136 C139
BS02 2YQ A H1184 G1185 G1205 G1206 Y1213 F1214 K1220 S1221 Y1224 I1228 H80 G81 G99 G100 Y107 F108 K114 S115 Y118 I122
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7kkn, PDBe:7kkn, PDBj:7kkn
PDBsum7kkn
PubMed33361107
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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