Structure of PDB 7kjv Chain A

Receptor sequence
>7kjvA (length=538) Species: 11678 (Human immunodeficiency virus type 1 BH10) [Search protein sequence]
PIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPE
NPYNTPVFAWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDV
GDAYFSVPLDEDFRKYTAFTIPIRYQYNVLPQGWKGSPAIFQSSMTKILE
PFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDK
KHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDICKLVGKLNWASQ
IYPGIKVRQLSKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYY
DPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLT
EAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNT
PPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPL
TNTTNQKTQLQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVN
QIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIR
3D structure
PDB7kjv High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A D76 R448 N474 Q500 H539 R557 D65 R429 N455 Q481 H520 R538
BS02 rna A M230 N255 C258 K259 R448 T473 Q475 M211 N236 C239 K240 R429 T454 Q456
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7kjv, PDBe:7kjv, PDBj:7kjv
PDBsum7kjv
PubMed33947853
UniProtP03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)

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