Structure of PDB 7kje Chain A

Receptor sequence
>7kjeA (length=310) Species: 1902 (Streptomyces coelicolor) [Search protein sequence]
VPPSLRLPVIEAAFPRQLHPYWPKLQETTRTWLLEKRLMPAYTDLMAGYY
LGAPDEVLQAIADYSAWFSVWDDRHDRDIVHGRAGAWRRLRGLLHTALDS
PGDHLHHEDTLVAGFADSVRRLYAFLPATWNARFARHFHTVIEAYDREFH
NRTRGIVPGVEEYLELRRLTFAHWIWTDLLEPSSGCELPDAVRKHPAYRR
AALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLITHHSLTLEEAIGEVR
RRVEECITEFLAVERDALRFADELADGTVRGKELSGAVRANVGNMRNWFS
SVYWFHHESG
3D structure
PDB7kje An Aromatic Cluster in the Active Site of epi -Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F95 S96 D99 D103 R179 R194 F198 N240 S244 K247 E248 G251 F332 H333
Catalytic site (residue number reindexed from 1) F68 S69 D72 D76 R152 R167 F171 N213 S217 K220 E221 G224 F305 H306
Enzyme Commision number 4.2.3.37: epi-isozizaene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D99 E175 D72 E148
BS02 NRD A L72 D99 R194 N240 F332 L45 D72 R167 N213 F305
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0052680 epi-isozizaene synthase activity

View graph for
Molecular Function
External links
PDB RCSB:7kje, PDBe:7kje, PDBj:7kje
PDBsum7kje
PubMed33270439
UniProtQ9K499|CYC1_STRCO Epi-isozizaene synthase (Gene Name=cyc1)

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