Structure of PDB 7kjc Chain A

Receptor sequence
>7kjcA (length=376) Species: 9606 (Homo sapiens) [Search protein sequence]
GPGDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSK
EVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMM
IITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRD
LAARNILVNSNLVCKVSDFGLSRVLEDDPEATYKIPIRWTAPEAISYRKF
TSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPS
AIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIR
LPSTPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVR
LPGHQKRIAYSLLGLKDQVNTVGIPI
3D structure
PDB7kjc Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D739 A741 R743 N744 D757 P780
Catalytic site (residue number reindexed from 1) D150 A152 R154 N155 D168 P186
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A I619 E623 A644 K646 M695 L746 D757 E765 I33 E37 A55 K57 M106 L157 D168 E176
BS02 MG A E663 D757 E74 D168
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7kjc, PDBe:7kjc, PDBj:7kjc
PDBsum7kjc
PubMed34857764
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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