Structure of PDB 7kja Chain A

Receptor sequence
>7kjaA (length=364) Species: 9606 (Homo sapiens) [Search protein sequence]
GPGDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSS
GKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYK
PMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYV
HRDLAARNILVNSNLVCKVSDFGPIRWTAPEAISYRKFTSASDVWSFGIV
MWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQ
ERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTPFRTVSEW
LESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSL
LGLKDQVNTVGIPI
3D structure
PDB7kja Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D739 A741 R743 N744 D757 P780
Catalytic site (residue number reindexed from 1) D153 A155 R157 N158 D171 P174
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A I619 G622 E623 A644 K646 M695 I33 G36 E37 A58 K60 M109
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7kja, PDBe:7kja, PDBj:7kja
PDBsum7kja
PubMed34857764
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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