Structure of PDB 7kir Chain A

Receptor sequence
>7kirA (length=326) Species: 9913 (Bos taurus) [Search protein sequence]
MSDILQELLRVSEKAANIARACRQQETLFQLDFKTLAAVLVQEVIKENME
NKFPGLGKKIFGEESNELTNDLGEKIIMRLGPTEEETVALLSKVLNGNKL
ASEALAKVVHQDVFFSDPALDSVEINIPQDILGIWVDPIDSTYQYIKGSA
DITPNQGIFPSGLQCVTVLIGVYDIQTGVPLMGVINQPFVSQDLHTRRWK
GQCYWGLSYLGTNIHSLLPPVSVVISTSEKETRIFRAAGAGYKSLCVILG
LADIYIFSEDTTFKWDSCAAHAILRAMGGGMVDLKECLERPQLVYHVGNQ
WANKGGLIAYRSEKQLETFLSRLLQH
3D structure
PDB7kir A structural basis for lithium and substrate binding of an inositide phosphatase.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.57: inositol-1,4-bisphosphate 1-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2IP A D156 S157 T158 S268 K270 G290 A291 K294 T312 D140 S141 T142 S228 K230 G239 A240 K243 T261
BS02 CA A D153 D156 D317 D137 D140 D266
BS03 CA A E79 D153 I155 E63 D137 I139
Gene Ontology
Molecular Function
GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0052829 inositol-1,3,4-trisphosphate 1-phosphatase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7kir, PDBe:7kir, PDBj:7kir
PDBsum7kir
PubMed33172890
UniProtP21327|INPP_BOVIN Inositol polyphosphate 1-phosphatase (Gene Name=INPP1)

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