Structure of PDB 7kie Chain A

Receptor sequence
>7kieA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
YELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVA
VKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIFE
YASKGNLREYLRARRPPGPEEQMTFKDLVSCTYQLARGMEYLASQKCIHR
DLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEAL
FDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP
ANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN
3D structure
PDB7kie Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3.
ChainA
Resolution2.47 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D626 R630 N631 D644
Catalytic site (residue number reindexed from 1) D151 R155 N156 D169
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WF7 A G488 E489 C491 A515 A567 S568 G570 L633 G23 E24 C26 A50 A102 S103 G105 L158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7kie, PDBe:7kie, PDBj:7kie
PDBsum7kie
PubMed33488969
UniProtP21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)

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