Structure of PDB 7khy Chain A

Receptor sequence
>7khyA (length=237) Species: 550 (Enterobacter cloacae) [Search protein sequence]
WQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLKRANQAFLPASTFAI
PNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVYQ
EFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQISFLR
KLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYDTKIGWWVGWVEL
DDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP
3D structure
PDB7khy Mechanistic Basis of OXA-48-like beta-Lactamases' Hydrolysis of Carbapenems.
ChainA
Resolution1.84 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S70 A73 S118 Y123 W157 Y211
Catalytic site (residue number reindexed from 1) S46 A49 S94 Y99 W133 Y187
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MER A S70 W105 S118 V120 T209 G210 Y211 L243 R246 S46 W81 S94 V96 T185 G186 Y187 L219 R222
BS02 ZN A H38 E252 H14 E228
Gene Ontology
Molecular Function
GO:0008658 penicillin binding
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0046677 response to antibiotic
GO:0071555 cell wall organization

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Molecular Function
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Biological Process
External links
PDB RCSB:7khy, PDBe:7khy, PDBj:7khy
PDBsum7khy
PubMed33492952
UniProtF6KZJ2

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