Structure of PDB 7khk Chain A

Receptor sequence
>7khkA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
NNYSYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSD
AAMTVAVKMLKPSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLV
ITEYCCYGDLLNFLRRKRDSFHENALDLEDLLSFSYQVAKGMAFLASKNC
IHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVDKARLPVKWMAPES
IFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMS
SPEHAPAEMYDIMKTCWDADPDKRPTFKQIVQDIEKQISES
3D structure
PDB7khk Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.
ChainA
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WEJ A L595 A621 K623 E640 T670 C673 C674 G676 L799 C809 D810 L30 A56 K58 E72 T102 C105 C106 G108 L161 C171 D172
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7khk, PDBe:7khk, PDBj:7khk
PDBsum7khk
PubMed34236401
UniProtP10721|KIT_HUMAN Mast/stem cell growth factor receptor Kit (Gene Name=KIT)

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