Structure of PDB 7khj Chain A

Receptor sequence
>7khjA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
NNYSYIDPTQLPYDHKWEFPRNRLSFGKTLGAGGKVVEATAQGLIKSDAA
MTVAVKMLKPSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVIT
EYCCYGDLLNFLRRKRDSFHNALDLEDLLSFSYQVAKGMAFLASKNCIHR
DLAARNILLTHGRITKICDFGLARVIKNDSNYVDKARLPVKWMAPESIFN
SVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPE
HAPAEMYDIMKTCWDADPDKRPTFKQIVQDIEKQISES
3D structure
PDB7khj Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WEG A Y672 C673 C674 Y675 G676 L799 Y102 C103 C104 Y105 G106 L158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7khj, PDBe:7khj, PDBj:7khj
PDBsum7khj
PubMed34236401
UniProtP10721|KIT_HUMAN Mast/stem cell growth factor receptor Kit (Gene Name=KIT)

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