Structure of PDB 7khg Chain A

Receptor sequence
>7khgA (length=327) Species: 9606 (Homo sapiens) [Search protein sequence]
HHHMPMYEVQWKVVEESNGNNYSYIDPTQLPYDHKWEFPRNRLSFGKTLG
AGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSY
LGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDSFHSSDTSP
ASMEDDENALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGR
ITKICDFGLARDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWS
YGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEHAPAEMYDIMK
TCWDADPDKRPTFKQIVQDIEKQISES
3D structure
PDB7khg Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P31 A W557 L595 V603 A621 E640 I653 C673 L799 I808 C809 D810 F811 W11 L49 V57 A75 E94 I107 C127 L195 I204 C205 D206 F207 BindingDB: IC50=27nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7khg, PDBe:7khg, PDBj:7khg
PDBsum7khg
PubMed34236401
UniProtP10721|KIT_HUMAN Mast/stem cell growth factor receptor Kit (Gene Name=KIT)

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