Structure of PDB 7kh8 Chain A

Receptor sequence
>7kh8A (length=155) Species: 9606 (Homo sapiens) [Search protein sequence]
GATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIG
NPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRK
SNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAF
LEKAH
3D structure
PDB7kh8 Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.2: acid phosphatase.
3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WE7 A L13 I16 Y49 E50 D129 Y131 Y132 L11 I14 Y47 E48 D127 Y129 Y130
Gene Ontology
Molecular Function
GO:0003993 acid phosphatase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009898 cytoplasmic side of plasma membrane
GO:0042383 sarcolemma
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kh8, PDBe:7kh8, PDBj:7kh8
PDBsum7kh8
PubMed33914534
UniProtP24666|PPAC_HUMAN Low molecular weight phosphotyrosine protein phosphatase (Gene Name=ACP1)

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