Structure of PDB 7kg0 Chain A

Receptor sequence
>7kg0A (length=497) Species: 9606 (Homo sapiens) [Search protein sequence]
KWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFPTH
YKDLWDNKHVKMPCSEQNLYPAGSRWELIQTALLNKFTRPQNLKDAILKY
NVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQ
PIPLLAAAMNHSITMSQEQIASLLANAFFCTFPRRNEYSSYPDINFNRLF
EGRSSRKPEKLKTLFCYFRRVTAAAPTGLVTFTRQSLEDFPEWERCEKPL
TRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPEL
IISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQ
RRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGVSSENLSAV
ATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMH
IFLTERKLTVGDVYKLLLRYYNEECRNCSTGPDIKLYPFIYHAVESC
3D structure
PDB7kg0 Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.
ChainA
Resolution1.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.143: poly(ADP-ribose) glycohydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WDA A Q754 Y795 A796 E797 F902 Q289 Y330 A331 E332 F437
Gene Ontology
Molecular Function
GO:0004649 poly(ADP-ribose) glycohydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006282 regulation of DNA repair

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7kg0, PDBe:7kg0, PDBj:7kg0
PDBsum7kg0
PubMed33636189
UniProtQ86W56|PARG_HUMAN Poly(ADP-ribose) glycohydrolase (Gene Name=PARG)

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