Structure of PDB 7kfn Chain A

Receptor sequence

>7kfnA (length=384) Species: 9606 (Homo sapiens)

LHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDA
KVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLN
NKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEE
PADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSC
SDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISN
IEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATT
GKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAAK
EYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT

3D structure

• PDB: 7kfn Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position.
• Chain: A
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 3.5.4.37: double-stranded RNA adenine deaminase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	V351 T375 K376 H394 E396 C451 R455 H460 H471 K475 S486 G487 E488 C516	V35 T59 K60 H78 E80 C135 R139 H144 H155 K159 S170 G171 E172 C200
BS02	rna	A	R348 I456 F457 H471 R474 R477 R481 G487 E488 I491 P492 R510 G593 K594	R32 I140 F141 H155 R158 R161 R165 G171 E172 I175 P176 R194 G277 K278
BS03	IHP	A	I397 R401 K519 R522 S531 K629 Y658 K662 Y668 K672 K690	I81 R85 K203 R206 S215 K313 Y342 K346 Y352 K356 K374
BS04	ZN	A	H394 C451 C516	H78 C135 C200

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004000 adenosine deaminase activity

Biological Process

• GO:0006396 RNA processing

External links

• PDB: RCSB:7kfn, PDBe:7kfn, PDBj:7kfn
• PDBsum: 7kfn
• PubMed: 33939417
• UniProt: P78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)