Structure of PDB 7kf6 Chain A

Receptor sequence
>7kf6A (length=1015) Species: 562 (Escherichia coli) [Search protein sequence]
IIRRSVANRFLVLMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYP
GQAPQIVENQVTYPLTTTMLSVPGAKTVRGFSQFGDSYVYVIFEDGTDPY
WARSRVLEYLNQVQGKLPAGVSAELGPDATGVGWIYEYALVDRSGKHDLA
DLRSLQDWFLKYELKTIPDVAEVASVGGVVKEYQVVIDPQRLAQYGISLA
EVKSALDASNQEAGGSSIELAEAEYMVRASGYLQTLDDFNHIVLKASENG
VPVYLRDVAKVQIGPEMRRGIAELNGEGEVAGGVVILRSGKNAREVIAAV
KDKLETLKSSLPEGVEIVTTYDRSQLIDRAIDNLSGKLLEEFIVVAVVCA
LFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMV
DAAIVMIENAHKRLEEWQHQKTRWQVITDASVEVGPALFISLLIITLSFI
PIFTLEGQEGRLFGPLAFTKTYAMAGAALLAIVVIPILMGYPLNRFLIRV
YHPLLLKVLHWPKTTLLVAALSVLTVLWPLNKVGGEFLPQINEGDLLYMP
STLPGISAAEAASMLQKTDKLIMSVPEVARVFGKTGKAETATDSAPLEMV
ETTIQLKPQEQWRPGMTMDKIIEELDNTVRLPGLANLWVPPIRNRIDMLS
TGIKSPIGIKVSGTVLADIDAMAEQIEEVARTVPGVASALAERLEGGRYI
NVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQ
SWRDSPQALRQLPILTPMKQQITLADVADIKVSTGPSMLKTENARPTSWI
YIDARDRDMVSVVHDLQKAIAEKVQLKPGTSVAFSGQFELLERANHKLKL
MVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSV
ATGTGFIALAGVAAEFGVVMLMYLRHAIEAVPSLNNPQTFSEQKLDEALY
HGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAP
LLSLFIIPAAYKLMW
3D structure
PDB7kf6 Cryo-EM Structures of CusA Reveal a Mechanism of Metal-Ion Export.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CU1 A M573 M623 E625 M672 M549 M599 E601 M648
Gene Ontology
Molecular Function
GO:0005375 copper ion transmembrane transporter activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0015080 silver ion transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
GO:0006812 monoatomic cation transport
GO:0006825 copper ion transport
GO:0006878 intracellular copper ion homeostasis
GO:0009636 response to toxic substance
GO:0010272 response to silver ion
GO:0010273 detoxification of copper ion
GO:0015673 silver ion transport
GO:0015679 plasma membrane copper ion transport
GO:0035434 copper ion transmembrane transport
GO:0042908 xenobiotic transport
GO:0046688 response to copper ion
GO:0055085 transmembrane transport
GO:0060003 copper ion export
GO:1902601 silver ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kf6, PDBe:7kf6, PDBj:7kf6
PDBsum7kf6
PubMed33820823
UniProtP38054|CUSA_ECOLI Cation efflux system protein CusA (Gene Name=cusA)

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