Structure of PDB 7kcl Chain A

Receptor sequence

>7kclA (length=612) Species: 9606 (Homo sapiens) [Search protein sequence]

PLHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISN
ASDALEKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTGIGMTQEELV
SNLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYS
RSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLKSDCKEFSSEAR
VRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVGEWQHEEFYRYVA
QAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVGSSVALYSRKVLIQ
TKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLI
KFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESS
ALPSGQLTSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTE
VLFCFEQFDELTLLHLREFDKKKLISVETDIVVDHCLSEKETEELMAWMR
NVLGSRVTNVKVTLRLDTHPAMVTVLEMGAARHFLRMQQLAKTQLLQPTL
EINPRHALIKKLNQLRASEPGLAQLLVDQIYENAMIAAGLVDDPRAMVGR
LNELLVKALERH

3D structure

PDB

7kcl Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates

Chain

Resolution

3.14 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	M352 V355 K382 E450 T454 L534 L537 H538 E614 H620 M624	M283 V286 K309 E377 T381 L461 L464 H465 E527 H533 M537
BS02	ANP	A	N119 A123 D158 M163 N171 S178 G179 S180 G199 Q200 F201 G202 V203 G204 F205 T251 R402	N50 A54 D89 M94 N102 S109 G110 S111 G130 Q131 F132 G133 V134 G135 F136 T182 R329

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATP hydrolysis activity
GO:0019901	protein kinase binding
GO:0051082	unfolded protein binding
GO:0140662	ATP-dependent protein folding chaperone

	Biological Process
GO:0006457	protein folding
GO:0009386	translational attenuation
GO:0060255	regulation of macromolecule metabolic process
GO:0061077	chaperone-mediated protein folding
GO:1901856	negative regulation of cellular respiration
GO:1903427	negative regulation of reactive oxygen species biosynthetic process
GO:1903751	negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide

	Cellular Component
GO:0005654	nucleoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0005759	mitochondrial matrix
GO:0016020	membrane
GO:0071944	cell periphery

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7kcl, PDBe:7kcl, PDBj:7kcl
PDBsum	7kcl
PubMed
UniProt	Q12931\|TRAP1_HUMAN Heat shock protein 75 kDa, mitochondrial (Gene Name=TRAP1)

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