Structure of PDB 7kc6 Chain A

Receptor sequence
>7kc6A (length=184) Species: 9606 (Homo sapiens) [Search protein sequence]
GSGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFST
SYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELG
ARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLH
KFASKPASEFVKILDTFEKLKDLFTELQKKIYVI
3D structure
PDB7kc6 Divergent conformational dynamics controls allosteric ligand accessibility across evolutionarily related I-domain-containing integrins
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 803 A I235 Y257 L302 I110 Y132 L177 BindingDB: Kd=12900nM,IC50=2400nM
BS02 MG A D137 S139 M140 D239 D12 S14 M15 D114
External links
PDB RCSB:7kc6, PDBe:7kc6, PDBj:7kc6
PDBsum7kc6
PubMed
UniProtP20701|ITAL_HUMAN Integrin alpha-L (Gene Name=ITGAL)

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