Structure of PDB 7kbt Chain A

Receptor sequence
>7kbtA (length=1233) Species: 9606,9823 [Search protein sequence]
AIRRYYLGLSWDYRQSELLRELHDTRYKKTVFVEFTDQLFSVARPRPPWM
GLLGPTIQAEVYDTVVVTLKNMASHPVSLHAVGVSFWKSSEGAEYEDHTS
QREKEDDKVLPGKQTYVWQVLKENGPTASDPPCLTYSYLSHVDLVKDLNS
GLIGALLVCREGSLTRERTQNLHEFVLLFAVFDEGKSWHSAAQPAMHTVN
GYVNRSLPGLIGCHKKSVYWHVIGMGTSPEVHSIFLEGHTFLVRHHRQAS
LEISPLTFLTAQTFLMDLGQFLLFCHISSHHHGGMEAHVRVESCAEKHPK
TWVHYIAAEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMA
YTDETFKTREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGI
TDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGPTKSDPRCLT
RYYSSFVNMERDLASGLIGPLLICYKSDKRNVILFSVFDENRSWYLTENI
QRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILS
IGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILG
CHNSDFRNRGMTALLKVSSCKRTRHYFIAAVEQLWDYGMSESPVPRFKKV
VFREFADGSFTQPSYRGELNKHLGLLGPYIRAEVEDNIMVTFKNQASRPY
SFYSSLISYPDDQEQGAEPRHNFVQPNETRTYFWKVQHHMAPTEDEFDCK
AWAYFSDVDLEKDVHSGLIGPLLICRANTLNAAHGRQVTVQEFALFFTIF
DETKSWYFTENVERNCTLKENYRFHAINGYVMDTLPGLVMAQNQRIRWYL
LSMGSNENIHSIHFSGHVFSVRKKEEYKMAVYNLYPGVFETVEMLPSKVG
IWRIECLIGEHLQAGMSTTFLVYSKKCQTPLGMASGHIRDFQITASGQYG
QWAPKLARLHYSGSINAWSTKEPFSWIKVDLLAPMIIHGIKTQGARQKFS
SLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSGIKHNIFNPPI
IARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQITASS
YFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVT
TQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVV
NSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCE
3D structure
PDB7kbt Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor
ChainA
Resolution4.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CU A H1954 I2002 H2005 H860 I908 H911
BS02 ZN A H268 C311 H318 H232 C275 H282
BS03 CA A K108 E123 D126 D127 K88 E103 D106 D107
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:7kbt, PDBe:7kbt, PDBj:7kbt
PDBsum7kbt
PubMed
UniProtP00451|FA8_HUMAN Coagulation factor VIII (Gene Name=F8);
P12263|FA8_PIG Coagulation factor VIII (Gene Name=F8)

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