Structure of PDB 7kac Chain A

Receptor sequence
>7kacA (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDV
STLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVT
GSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADF
FIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPD
RVLELMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSH
QLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIE
3D structure
PDB7kac Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1).
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D137 K139 A141 N142 D155 T175
Catalytic site (residue number reindexed from 1) D131 K133 A135 N136 D149 T154
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W9D A L23 G24 V31 A44 V75 M91 E92 F93 C94 G95 D101 L144 D155 L17 G18 V25 A38 V69 M85 E86 F87 C88 G89 D95 L138 D149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7kac, PDBe:7kac, PDBj:7kac
PDBsum7kac
PubMed33439152
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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