Structure of PDB 7ka0 Chain A

Receptor sequence
>7ka0A (length=339) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
MLSPEALTTAVDAAQQAIALADTLDVLARVKTEHLGDRSPLALARQALAV
LPKEQRAEAGKRVNAARNAAQRSYDERLATLRAERDAAVLVAEGIDVTLP
STRVPAGARHPIIMLAEHVADTFIAMGWELAEGPEVETEQFNFDALNFPA
DHPARGEQDTFYIAPEDSRQLLRTHTSPVQIRTLLARELPVYIISIGRTF
RTDELDATHTPIFHQVEGLAVDRGLSMAHLRGTLDAFARAEFGPSARTRI
RPHFFPFTEPSAEVDVWFANKGAAWVEWGGCGMVHPNVLRATGIDPDLYS
GFAFGMGLERTLQFRNGIPDMRDMVEGDVRFSLPFGVGA
3D structure
PDB7ka0 Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R45 L48 R56 G60 K61 N64 R45 L48 R56 G60 K61 N64
BS02 PHE A H175 E217 F255 F257 G282 C283 A305 F306 G307 H175 E217 F255 F257 G280 C281 A303 F304 G305
BS03 MG A E259 H287 E259 H285
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ka0, PDBe:7ka0, PDBj:7ka0
PDBsum7ka0
PubMed33885823
UniProtP9WFU3|SYFA_MYCTU Phenylalanine--tRNA ligase alpha subunit (Gene Name=pheS)

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