Structure of PDB 7k84 Chain A

Receptor sequence
>7k84A (length=793) Species: 1491 (Clostridium botulinum) [Search protein sequence]
MPKINSFNYNDPVNDRTILYIKPGGCQEFYKSFNIMKNIWIIPERNVIGT
TPQDFHPPTSLKNGDSSYYDPNYLQSDEEKDRFLKIVTKIFNRINNNLSG
GILLEELSKANPYLGNDNTPDNQFHIGDASAVEIKFSNGSQDILLPNVII
MGAEPDLFETNSSNISLRNNYMPSNHGFGSIAIVTFSPEYSFRFNDNSMN
EFIQDPALTLMHELIHSLHGLYGAKGITTKYTITQKQNPLITNIRGTNIE
EFLTFGGTDLNIITSAQSNDIYTNLLADYKKIASKLSKVQVSNPLLNPYK
DVFEAKYGLDKDASGIYSVNINKFNDIFKKLYSFTEFDLATKFQVKCRQT
YIGQYKYFKLSNLLNDSIYNISEGYNINNLKVNFRGQNANLNPRIITPIT
GRGLVKKIIRFCKNIVSVKGIRKSICIEINNGELFFVASENSYNDDNINT
PKEIDDTVYIPKYDSNGTSDIEQHDVNELNVFFYLDAQKVPEGENNVNLT
SSIDTALLEQPKIYTFFSSEFINNVNKPVQAALFVSWIQQVLVDFTTEAN
QKSTVDKIADISIVVPYIGLALNIGNEAQKGNFKDALELLGAGILLEFEP
ELLIPTILVFTIKSFLGSSDNKNKVIKAINNALKERDEKWKEVYSFIVSN
WMTKINTQFNKRKEQMYQALQNQVNAIKTIIESKYNSYTLEEKNELTNKY
DIKQIENELNQKVSIAMNNIDRFLTESSISYLMKLINEVKINKLREYDEN
VKTYLLNYIIQHGSILGESQQELNSMVTDTLNNSIPFKLSSYT
3D structure
PDB7k84 Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.69: bontoxilysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H212 H216 E251 H212 H216 E251
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
GO:0008320 protein transmembrane transporter activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7k84, PDBe:7k84, PDBj:7k84
PDBsum7k84
PubMed32992561
UniProtQ00496|BXE_CLOBO Botulinum neurotoxin type E (Gene Name=botE)

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