Structure of PDB 7k7o Chain A

Receptor sequence
>7k7oA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
SFHRVDQKEITQLSHLGQGTRTNVYEGRLRELRVVLKVLDPSHHDIALAF
YETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGH
VPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFI
KLSDPGVGLGALSREERVERIPWLAPECLPLSTAMDKWGFGATLLEICFD
GEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFR
TILRDLT
3D structure
PDB7k7o Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.
ChainA
Resolution2.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VZJ A Q597 G598 V603 V640 K642 T687 E688 Y689 V690 E691 G693 R738 L741 Q18 G19 V24 V35 K37 T82 E83 Y84 V85 E86 G88 R133 L136
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7k7o, PDBe:7k7o, PDBj:7k7o
PDBsum7k7o
PubMed33370104
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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