Structure of PDB 7k71 Chain A

Receptor sequence
>7k71A (length=843) Species: 9606 (Homo sapiens) [Search protein sequence]
EEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNS
PHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYT
LKINHDCVPEQVIAEAIRKKTRSQGKYILKVCGCDEYFLEKYPLSQYKYI
RSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSTKSLWVINSALRIKI
LCATYVNIDKIYVRTGIYHGGEPLCDNVNTQRVPRWNEWLNYDIYIPDLP
RAARLCLSICSVKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLE
DLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVREN
DKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNS
RDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDD
KLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMH
NKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDE
TQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAK
RPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQN
QGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKNSHTLHQWLKDKN
KGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFG
HFLDLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINL
FSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMN
3D structure
PDB7k71 Structure-Based Drug Design and Synthesis of PI3K alpha-Selective Inhibitor (PF-06843195).
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VYP A D810 I848 V851 I932 D933 D634 I672 V675 I747 D748 BindingDB: EC50=130nM,IC50=14nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7k71, PDBe:7k71, PDBj:7k71
PDBsum7k71
PubMed33356246
UniProtP42336|PK3CA_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Gene Name=PIK3CA)

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