Structure of PDB 7k6o Chain A

Receptor sequence
>7k6oA (length=852) Species: 9606 (Homo sapiens) [Search protein sequence]
EEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNS
PHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYT
LKINHDCVPEQVIAEAIRKKTRSQGKYILKVCGCDEYFLEKYPLSQYKYI
RSCIMLGRMPNLMLMAKESLYSQLPMTMPSYSTKSLWVINSALRIKILCA
TYVNIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDL
PRAARLCLSICSVKGRKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVP
HGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWS
VRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSV
KWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKY
LTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLK
SEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQE
KKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIM
SSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMEN
IWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQF
NSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIM
VKDDGQLFHIDFGHFLDFVLTQDFLIVITKTREFERFQEMCYKAYLAIRQ
HANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQM
ND
3D structure
PDB7k6o Structure-Based Drug Design and Synthesis of PI3K alpha-Selective Inhibitor (PF-06843195).
ChainA
Resolution2.738 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VY1 A R770 M772 W780 K802 D810 I848 E849 V851 Q859 M922 D933 R598 M600 W608 K630 D638 I676 E677 V679 Q687 M750 D761 BindingDB: Ki=0.124nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7k6o, PDBe:7k6o, PDBj:7k6o
PDBsum7k6o
PubMed33356246
UniProtP42336|PK3CA_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Gene Name=PIK3CA)

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