Structure of PDB 7k66 Chain A

Receptor sequence
>7k66A (length=1265) Species: 9606,9823 [Search protein sequence]
AIRRYYLGAVELSWDYRQSELLRELHVDTRFPATAPSVLYKKTVFVEFTD
QLFSVARPRPPWMGLLGPTIQAEVYDTVVVTLKNMASHPVSLHAVGVSFW
KSSEGAEYEDHTSQREKEDDKVLPGKSQTYVWQVLKENGPTASDPPCLTY
SYLSHVDLVKDLNSGLIGALLVCREGSLTRERTQNLHEFVLLFAVFDEGK
SWHSAAQPAMHTVNGYVNRSLPGLIGCHKKSVYWHVIGMGTSPEVHSIFL
EGHTFLVRHHRQASLEISPLTFLTAQTFLMDLGQFLLFCHISSHHHGGME
AHVRVESCAEDGDDVSPFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVL
APDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILG
PLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKD
FPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGP
LLICYKESDKRNVILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQA
SNIMHSINGYVFDSLQLSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKH
KMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRGMTALLKVSS
CKRTRHYFIAAVEQLWDYGMSESVPRFKKVVFREFADGSFTQPSYRGELN
KHLGLLGPYIRAEVEDNIMVTFKNQASRPYSFYSSLISYPDDQEQGAEPR
HNFVQPNETRTYFWKVQHHMAPTEDEFDCKAWAYFSDVDLEKDVHSGLIG
PLLICRANTLNAAHGRQVTVQEFALFFTIFDETKSWYFTENVERNCTLKE
NYRFHAINGYVMDTLPGLVMAQNQRIRWYLLSMGSNENIHSIHFSGHVFS
VRKKEEYKMAVYNLYPGVFETVEMLPSKVGIWRIECLIGEHLQAGMSTTF
LVYSKKCQTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSGSINAWST
KEPFSWIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQT
YRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRM
ELMGCDLNSCSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQG
RSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISS
SQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWV
HQIALRMEVLGCEAQ
3D structure
PDB7k66 Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody inhibitor.
ChainA
Resolution3.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CU A H1954 H2005 H890 H941
BS02 CA A K108 E123 D126 D127 K101 E116 D119 D120
BS03 ZN A H268 H318 H246 H296
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:7k66, PDBe:7k66, PDBj:7k66
PDBsum7k66
PubMed33529335
UniProtP00451|FA8_HUMAN Coagulation factor VIII (Gene Name=F8);
P12263|FA8_PIG Coagulation factor VIII (Gene Name=F8)

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