Structure of PDB 7k4d Chain A

Receptor sequence
>7k4dA (length=612) Species: 9606 (Homo sapiens) [Search protein sequence]
SWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRGA
MGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVVN
QNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEE
IVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGD
HLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTL
YDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRYGRP
YFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEAY
MTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTILGGPFHV
LIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGP
FTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYP
MALFSTFELFLTIIDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIAM
MGDTHWRVAHERDELWRAQIVATTVMLERKLPRCLWPRSGICGREYGLGD
RWFLRVEDRQDL
3D structure
PDB7k4d Inactivation-mimicking block of the epithelial calcium channel TRPV6.
ChainA
Resolution3.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VUM A F425 F456 C463 I482 Q483 F398 F429 C436 I455 Q456
BS02 VUM A G579 W583 G552 W556
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7k4d, PDBe:7k4d, PDBj:7k4d
PDBsum7k4d
PubMed33246965
UniProtQ9H1D0|TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6 (Gene Name=TRPV6)

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