Structure of PDB 7k4a Chain A

Receptor sequence
>7k4aA (length=605) Species: 9606 (Homo sapiens) [Search protein sequence]
RRESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQ
RGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIA
VVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVN
SEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDR
HGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLT
STLYDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRY
GRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQ
EAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRPFHVLIITYA
FMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQ
KMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYPMALFST
FELFLTIIDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHW
RVAHERDELWRAQIVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRV
EDRQD
3D structure
PDB7k4a Inactivation-mimicking block of the epithelial calcium channel TRPV6.
ChainA
Resolution3.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A Y339 I399 E403 F425 H426 Y467 M603 Y315 I375 E379 F392 H393 Y434 M570
BS02 Y01 A P424 F425 F456 R470 T479 I480 Q483 P391 F392 F423 R437 T446 I447 Q450
BS03 Y01 A M497 P527 M464 P494
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7k4a, PDBe:7k4a, PDBj:7k4a
PDBsum7k4a
PubMed33246965
UniProtQ9H1D0|TRPV6_HUMAN Transient receptor potential cation channel subfamily V member 6 (Gene Name=TRPV6)

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