Structure of PDB 7k2e Chain A

Receptor sequence
>7k2eA (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
IYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAV
GGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYA
VGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGG
FDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG
QDQLNSVERYDVATATWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTF
LDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
3D structure
PDB7k2e Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning.
ChainA
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y334 S363 R380 N382 R415 R483 S508 G509 Y525 Q530 S555 A556 Y572 F577 S602 Y7 S36 R53 N55 R88 R156 S181 G182 Y198 Q203 S228 A229 Y245 F250 S275
External links
PDB RCSB:7k2e, PDBe:7k2e, PDBj:7k2e
PDBsum7k2e
PubMed33683866
UniProtQ14145|KEAP1_HUMAN Kelch-like ECH-associated protein 1 (Gene Name=KEAP1)

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