Structure of PDB 7k1i Chain A

Receptor sequence

>7k1iA (length=288) Species: 9606 (Homo sapiens)

NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE
ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLL
DYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ
HVKITDFGRVPIKWMALESIIYTHQSDVWSYGVTVWELMTFGSKPYDGIP
ASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFS
KMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM

3D structure

• PDB: 7k1i Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
• Chain: A
• Resolution: 3.202 Å

Enzymatic activity

• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	N842 D855	N143 D156
BS02	ANP	A	G719 G721 V726 A743 K745 M793 C797 D837 R841 N842 L844 D855 R858	G20 G22 V27 A44 K46 M94 C98 D138 R142 N143 L145 D156 R159
BS03	VNS	A	V726 A743 I744 K745 I759 M766 C775 R776 L777 L788 T790 D855 F856	V27 A44 I45 K46 I60 M67 C76 R77 L78 L89 T91 D156 F157

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:7k1i, PDBe:7k1i, PDBj:7k1i
• PDBsum: 7k1i
• UniProt: P00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)