Structure of PDB 7k1h Chain A

Receptor sequence
>7k1hA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREA
TSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLD
YVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH
VKITDFGRAVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYD
GIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELII
EFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM
3D structure
PDB7k1h Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
ChainA
Resolution2.602 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VNS A V726 A743 I744 K745 E758 I759 M766 R776 L777 L788 T790 D855 F856 R858 V26 A43 I44 K45 E58 I59 M66 R76 L77 L88 T90 D155 F156 R158
BS02 YY3 A L718 G719 V726 L792 M793 G796 C797 L844 D855 L18 G19 V26 L92 M93 G96 C97 L144 D155 BindingDB: IC50=2.0nM,Ki=14nM,EC50=6.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7k1h, PDBe:7k1h, PDBj:7k1h
PDBsum7k1h
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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