Structure of PDB 7k0g Chain A

Receptor sequence
>7k0gA (length=296) Species: 694009 (Severe acute respiratory syndrome-related coronavirus) [Search protein sequence]
HHSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAED
MLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKT
PKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSV
GFNIDYDCVSFCYMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDT
TITLNVLAWLYAAVINGDRWFLFTTTLNDFNLVAMKYNYEPLTQDHVDIL
GPLSAQTGIAVLDMCAALKELLQNGTILGSTILEDEFTPFDVVRQC
3D structure
PDB7k0g Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K36 A H41 M49 F140 C145 H163 H164 M165 E166 D187 Q189 H43 M51 F142 C147 H165 H166 M167 E168 D189 Q191
BS02 B1S A H41 M49 F140 C145 H163 H164 M165 E166 D187 Q189 H43 M51 F142 C147 H165 H166 M167 E168 D189 Q191
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:7k0g, PDBe:7k0g, PDBj:7k0g
PDBsum7k0g
PubMed34210738
UniProtP0C6U8|R1A_SARS Replicase polyprotein 1a (Gene Name=1a)

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