Structure of PDB 7jxx Chain A

Receptor sequence
>7jxxA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
DILPANYVVKDRWKVLKKIGGGFGEIYEAMDLLTRENVALKVESAQQPKQ
VLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQP
RGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKC
YMLDFGLARQYTNTDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWS
LFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDH
IASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEK
3D structure
PDB7jxx Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo.
ChainA
Resolution1.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VP7 A I48 A61 K63 E77 M107 Q110 D176 F177 I26 A39 K41 E55 M85 Q88 D154 F155
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7jxx, PDBe:7jxx, PDBj:7jxx
PDBsum7jxx
PubMed33944571
UniProtQ5TCY1|TTBK1_HUMAN Tau-tubulin kinase 1 (Gene Name=TTBK1)

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