Structure of PDB 7jxw Chain A

Receptor sequence
>7jxwA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELSP
KANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVR
EHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKI
TDFGLAVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIP
ASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFS
KMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM
3D structure
PDB7jxw Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YY3 A L718 G719 S720 V726 A743 M790 L792 M793 G796 C797 D800 R841 L844 L19 G20 S21 V27 A44 M87 L89 M90 G93 C94 D97 R138 L141 BindingDB: IC50=2.0nM,Ki=14nM,EC50=6.0nM
BS02 VNS A A743 I744 K745 E758 I759 M766 R776 L777 L788 M790 D855 F856 L858 A44 I45 K46 E55 I56 M63 R73 L74 L85 M87 D152 F153 L155
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7jxw, PDBe:7jxw, PDBj:7jxw
PDBsum7jxw
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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