Structure of PDB 7jxp Chain A

Receptor sequence

>7jxpA (length=308) Species: 9606 (Homo sapiens) [Search protein sequence]

NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE
ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLL
DYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ
HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWS
YGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRK
CWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYR
ALMDEEDM

3D structure

PDB

7jxp Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors

Chain

Resolution

2.16 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.10.1: receptor protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ANP	A	L718 G719 S720 G721 A722 V726 A743 K745 M790 M793 C797 D837 R841 N842 L844	L19 G20 S21 G22 A23 V27 A44 K46 M91 M94 C98 D138 R142 N143 L145
BS02	MG	A	N842 D855	N143 D156
BS03	JBJ	A	V726 A743 I744 K745 L747 I759 M766 R776 L777 L788 M790 D855 F856 L858 L861 L862 E865	V27 A44 I45 K46 L48 I60 M67 R77 L78 L89 M91 D156 F157 L159 L162 L163 E166	BindingDB: IC50=>1000nM

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7jxp, PDBe:7jxp, PDBj:7jxp
PDBsum	7jxp
PubMed
UniProt	P00533\|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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