Structure of PDB 7jxm Chain A

Receptor sequence
>7jxmA (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRP
KANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVR
EHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKI
TDFGLAKLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG
IPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIE
FSKMARDPQRYLVIQGDERPSPTDSNFYRALMDEEDM
3D structure
PDB7jxm Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
ChainA
Resolution2.192 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A G719 G721 V726 A743 M790 M793 C797 D837 R841 N842 L844 D855 G20 G22 V27 A44 M87 M90 C94 D134 R138 N139 L141 D152
BS02 MG A N842 D855 N139 D152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7jxm, PDBe:7jxm, PDBj:7jxm
PDBsum7jxm
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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