Structure of PDB 7jwe Chain A

Receptor sequence
>7jweA (length=815) Species: 9606 (Homo sapiens) [Search protein sequence]
EESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPK
LYAMHPWVTSKPLPEYLWKKIANNCIFIVIHSQTIKVSPDDTPGAILQSF
FTQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPAL
DEVRKECDRKFRVKIRGIDIPVLDLTVFVEANIQHGQQVLCQRRTSPKPF
TEEVLWNVWLEFSIKIKDLPKGALLNLQIYCQLLYYVNLLLIDHRFLLRR
GEYVLHMWQISGFNADKLTSATNPDKENSMSISILLDNAEMPNQLRKQLE
AIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAK
TYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDV
LHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQS
RHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEK
YDVSSQVISQLKQKLENLQNPESFRVPYDPGLKAGALAIEKCKVMASKKK
PLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETES
LDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNH
WLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGN
LFHIDFGHILRVPFVLTPDFLFVMGTTSPHFQKFQDICVKAYLALRHHTN
LLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVC
RDKGWTVQFNWFLHL
3D structure
PDB7jwe Disease related mutations in PI3K gamma disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VL1 A M804 D836 D837 D841 Y867 E880 I881 V882 M953 I963 D964 G966 H967 M1039 M545 D577 D578 D582 Y608 E621 I622 V623 M694 I704 D705 G707 H708 M764 BindingDB: IC50=6.0nM,Kd=24nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7jwe, PDBe:7jwe, PDBj:7jwe
PDBsum7jwe
PubMed33661099
UniProtP48736|PK3CG_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Gene Name=PIK3CG)

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