Structure of PDB 7jvn Chain A

Receptor sequence
>7jvnA (length=476) Species: 9606 (Homo sapiens) [Search protein sequence]
RRWFHPNITGVEAENLLLTRGVDGSFLARPSNPGDFTLSVRRNGAVTHIK
IQNTGDYYDLYGGEKFATLAELVQYYMEHGQLKIELKYPLNCADPTSERW
FHGHLSGKEAEKLLTEKGKHGSFLVREPGDFVLSVRTGDSKVTHVMIRCQ
ELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAE
IESRVRELSKLQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNIL
PFDHTRVVLHDGDPSDYINANIIMPKSYIATQGCLQNTVNDFWRMVFQEN
SRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLR
ELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESI
MDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRS
QRSGMVQTEAQYRFIYMAVQHYIETL
3D structure
PDB7jvn Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.
ChainA
Resolution1.917 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VKP A R111 F113 H114 T219 E249 E250 T253 L254 P491 K492 Q495 R99 F101 H102 T194 E216 E217 T220 L221 P442 K443 Q446 MOAD: ic50=0.029uM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7jvn, PDBe:7jvn, PDBj:7jvn
PDBsum7jvn
PubMed32910655
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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