Structure of PDB 7jvm Chain A

Receptor sequence
>7jvmA (length=486) Species: 9606 (Homo sapiens) [Search protein sequence]
SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVT
HIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKDVIELKYPLNCAD
PTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESPGDFVLSVRTGDSKVT
HVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNT
TRINAAEIESRVRELSKLQGFWEEFETLQQQECKLLYSRKEGQRQENKNK
NRYKNILPFDHTRVVLHDGDPPVSDYINANIIMPEKSYIATQGCLQNTVN
DFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVK
ESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFL
EEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDID
VPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL
3D structure
PDB7jvm Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.
ChainA
Resolution2.166 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VKS A T108 E110 R111 F113 H114 T219 E250 T253 L254 Q257 P491 K492 Q495 T102 E104 R105 F107 H108 T201 E224 T227 L228 Q231 P452 K453 Q456 MOAD: ic50=0.011uM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7jvm, PDBe:7jvm, PDBj:7jvm
PDBsum7jvm
PubMed32910655
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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