Structure of PDB 7juz Chain A

Receptor sequence
>7juzA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
VYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDH
LKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRD
PKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITD
FGLFGISGVQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFG
TVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSA
CWAFDLQERPSFSLLMDMLEKLP
3D structure
PDB7juz Structural basis for the action of the drug trametinib at KSR-bound MEK.
ChainA
Resolution3.21 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D733 K737 N738 D750
Catalytic site (residue number reindexed from 1) D133 K137 N138 D150
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A I619 A637 R639 F688 C689 K735 N738 F740 D750 I19 A37 R39 F88 C89 K135 N138 F140 D150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7juz, PDBe:7juz, PDBj:7juz
PDBsum7juz
PubMed32927473
UniProtQ8IVT5|KSR1_HUMAN Kinase suppressor of Ras 1 (Gene Name=KSR1)

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