Structure of PDB 7ju8 Chain A

Receptor sequence
>7ju8A (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNF
TRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDD
DETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKFMLP
DDDVQGIQSLYGPGDED
3D structure
PDB7ju8 Indole Inhibitors of MMP-13 for Arthritic Disorders
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H222 H226 H232 H119 H123 H129
BS02 ZN A H172 D174 H187 H200 H69 D71 H84 H97
BS03 CA A D179 G180 S182 L184 D202 E205 D76 G77 S79 L81 D99 E102
BS04 CA A D162 N194 G196 D198 D59 N91 G93 D95
BS05 9DY A V219 H222 L239 F241 P242 I243 Y244 V116 H119 L136 F138 P139 I140 Y141
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ju8, PDBe:7ju8, PDBj:7ju8
PDBsum7ju8
PubMed
UniProtP45452|MMP13_HUMAN Collagenase 3 (Gene Name=MMP13)

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