Structure of PDB 7jsj Chain A

Receptor sequence
>7jsjA (length=468) Species: 9606 (Homo sapiens) [Search protein sequence]
SFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLM
PVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALR
TLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQRKRL
CKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWF
AFAFPNMLVMLLFAWLWLQFVYMRSKKNEKAALKVLQEEYRKLGPLSFAE
INVLICFFLLVILWFSRDPETKYVSDATVAIFVATLLFIVPSQKPKFYPP
PLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVP
PAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPC
TLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAV
NTWGRAIFDLDHFPDWAN
3D structure
PDB7jsj Structure and inhibition mechanism of the human citrate transporter NaCT.
ChainA
Resolution3.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X3M A N141 T142 T227 G409 I410 N465 N129 T130 T173 G315 I316 N371 BindingDB: IC50=15849nM
BS02 NA A S136 I139 S140 N141 G226 S124 I127 S128 N129 G172
BS03 NA A T460 T463 S464 N465 A507 T508 T366 T369 S370 N371 A413 T414
Gene Ontology
Molecular Function
GO:0005343 organic acid:sodium symporter activity
GO:0005515 protein binding
GO:0015137 citrate transmembrane transporter activity
GO:0015141 succinate transmembrane transporter activity
GO:0015142 tricarboxylic acid transmembrane transporter activity
GO:0015293 symporter activity
GO:0015370 solute:sodium symporter activity
GO:0017153 sodium:dicarboxylate symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0006842 tricarboxylic acid transport
GO:0015729 oxaloacetate transport
GO:0015741 fumarate transport
GO:0015742 alpha-ketoglutarate transport
GO:0015744 succinate transport
GO:0015746 citrate transport
GO:0035674 tricarboxylic acid transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071285 cellular response to lithium ion
GO:0071422 succinate transmembrane transport
GO:1903825 organic acid transmembrane transport
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jsj, PDBe:7jsj, PDBj:7jsj
PDBsum7jsj
PubMed33597751
UniProtQ86YT5|S13A5_HUMAN Na(+)/citrate cotransporter (Gene Name=SLC13A5)

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